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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract:

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediatingRecent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Patrick A. Carroll, Brian W. Freie, Haritha Mathsyaraja, Robert N. Eisenman

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 412-425 doi: 10.1007/s11684-018-0650-z

Abstract:

Transcription factor networks have evolved in order to control, coordinate, and separate, the functions

Keywords： network     transcription     cancer     MYC     MAX     MLX    

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play

Keywords： climacteric fruit ripening / phytohormones / TFs / epigenetic modifications    

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Yinglin JI, Mingyang XU, Aide WANG

Frontiers of Agricultural Science and Engineering   Pages 314-334 doi: 10.15302/J-FASE-2021386

Abstract: Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play

Keywords： climacteric fruit ripening     phytohormones     TFs     epigenetic modifications    

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Characterization of chromatin accessibility in psoriasis

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 483-495 doi: 10.1007/s11684-021-0872-3

Abstract: Our results provided candidate transcription factors and a foundational framework of the regulomes of

Keywords： psoriasis     ATAC-seq     epigenetics     transcription factor    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: of tumor suppressor XAF1 gene expression in digestive system cancers, we studied XAF1 gene promoter transcriptionpolymerase chain reaction (PCR) and cloned into pGL3-basic vector and pEGFP-1 vector to assay its promoter transcriptionThe promoter transcription activity was determined by dual-luciferase report assay, and enhanced greenThe dual-luciferase reporter assay showed that the promoter transcription activity in digestive systemremarkably down-regulated XAF1 mRNA expression in digestive system cancer cell lines may be due to loss of transcription

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 541-550 doi: 10.1007/s11684-020-0780-y

Abstract: Synthetic lethal screening, which exploits the combination of mutations that result in cell death, is a promising method for identifying novel drug targets. This method provides a new avenue for targeting “undruggable” proteins, such as c-Myc. Here, we revisit current methods used to target c-Myc and discuss the important functional nodes related to c-Myc in non-oncogene addicted network, whose inhibition may cause a catastrophe for tumor cell destiny but not for normal cells. We further discuss strategies to identify these functional nodes in the context of synthetic lethality. We review the progress and shortcomings of this research field and look forward to opportunities offered by synthetic lethal screening to treat tumors potently.

Keywords： synthetic lethality     undruggable     transcription factor     c-Myc    

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The genetic regulation of skeletal muscle development: insights from chicken studies

Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 295-304 doi: 10.15302/J-FASE-2017159

Abstract: development in the chicken, such as gene polymorphisms, epigenetic modification, noncoding RNAs and transcription

Keywords： chicken     epigenetic modification     miRNAs     skeletal muscle development     SNP     transcription factor    

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Genetic biosensors for small-molecule products: Design and applications in high-throughput screening

Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 15-26 doi: 10.1007/s11705-017-1629-z

Abstract: Overproduction of small-molecule chemicals using engineered microbial cells has greatly reduced the production cost and promoted environmental protection. Notably, the rapid and sensitive evaluation of the concentrations of the desired products greatly facilitates the optimization process of cell factories. For this purpose, many genetic components have been adapted into biosensors of small molecules, which couple the intracellular concentrations of small molecules to easily detectable readouts such as fluorescence, absorbance, and cell growth. Such biosensors allow a high-throughput screening of the small-molecule products, and can be roughly classified as protein-based and RNA-based biosensors. This review summarizes the recent developments in the design and applications of biosensors for small-molecule products.

Keywords： biosensor     small molecule product     transcription factor     riboswitch     high-throughput screening    

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Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review

Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 104-113 doi: 10.15302/J-FASE-2014003

Abstract: The cytoplasmic milieu most likely contains all of the specific transcription and/or reprogramming factorsCertain transcription factors in the cytoplast may be critical as has been demonstrated for induced pluripotentThe maternal pronucleus exerts a predominant, transcription-dependent effect on embryo cytofragmentationWith deep analysis of transcriptomics in oocytes and early developmental stage embryos more maternal transcription

Keywords： nuclear reprogramming     somatic cell     transcription factors     transcriptomics    

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Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 475-479 doi: 10.1007/s11684-009-0086-6

Abstract: The expression of signal transducer and activator of transcription 6 (STAT6) and nuclear factor-κ

Keywords： ulcerative colitis     signal transducer and activator of transcription 6 (STAT6)     nuclear factor-κ     B    

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Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract:

Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkheadbox protein A2 (FOXA2) are key transcription factors that regulate a complex gene network in the liverThe Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors inbinding to the 10 candidate glyco-genes studied in this work confirms a significant enrichment of these transcriptionHere, we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene

Keywords： regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9)     Epigenetics     Hepatocyte nuclear factor1 alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)     N-glycosylation    

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LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 7,   Pages 871-881 doi: 10.1007/s11709-022-0863-8

Abstract: failure criteria of practical soil mass are very complex, and have significant influence on the safety factorto determine the failure criterion, the limit equilibrium method can be used to calculate the safety factorAnalysis of results of the safety factor of two three-dimensional homogeneous slopes shows that the maximum

Keywords： slope stability     safety factor     failure criterion     least square support vector machine    

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: Moreover, serine/arginine-rich splicing factor 10 (SRSF10) knockdown increased the LC3II/LC3IMechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy

Keywords： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 6,   Pages 1015-1024 doi: 10.1007/s11783-014-0670-0

Abstract: land area types with different levels of productivity, they introduced the concept of an equivalence factorSecondly, China’s equivalence factor for 6 land area types was calculated based on NPP: arable land andbuilt-up land has an equivalence factor of 1.71, forest and fossil energy land has a factor of 1.41,pasture has a factor of 0.44 and water/fishery 0.35; Finally, the equivalence factor of 6 land areaThe NPP of each ecosystem type varies along with the equivalence factor in different provinces.

Keywords： ecological footprint     equivalence factor     net primary production     biological capacity     land types    

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Title Author Date Type Operation

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Patrick A. Carroll, Brian W. Freie, Haritha Mathsyaraja, Robert N. Eisenman

Journal Article

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Journal Article

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Yinglin JI, Mingyang XU, Aide WANG

Journal Article

Characterization of chromatin accessibility in psoriasis

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

Journal Article

The genetic regulation of skeletal muscle development: insights from chicken studies

Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG

Journal Article

Genetic biosensors for small-molecule products: Design and applications in high-throughput screening

Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang

Journal Article

Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review

Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI

Journal Article

Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis

Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,

Journal Article

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

Journal Article

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article

The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

Journal Article